Breakthrough in the synthesis and application of tert butyl hydrazine formate

Tert butyl hydrazine formate (CAS 870-46-2, molecular formula C5H12N2O2) is a high-purity (≥ 98%) white to pale yellow crystal with a melting point of 39-42 ℃ and a boiling point of 303.58 ℃. It needs to be sealed and stored in a cool, dry environment away from light. As a key intermediate of BOC protective reagents, it is widely used in the fields of medicine, pesticides, and materials science.
Core strengths
High purity and stability: Strict quality control ensures reaction selectivity and reduces the generation of by-products.
Mild synthesis process: Using benzyl chloroformate as the raw material, the total yield is 71.7% through two steps of esterification and hydrazine reaction. The solvent is recyclable and environmentally friendly and efficient.
Multifunctionality: Supports solid-phase peptide synthesis, preparation of HIV-1 inhibitor intermediates, and optical purity determination.
The high purity and stability of tert butyl hydrazine formate, as a key intermediate for BOC protecting groups, provide reliable guarantees for the synthesis of complex drug molecules. In the development of antiviral, antidepressant, and neuroprotective drugs, this compound selectively protects amino groups, significantly improving reaction efficiency and product yield, becoming an indispensable molecular block in modern pharmaceutical chemistry.