中文
In recent years, GLP-1 peptide drugs like semaglutide have taken the market by storm, driving the entire peptide synthesis sector to new heights. Behind every peptide synthesis route, one reagent quietly performs a critical task—putting on and taking off “protective suits” for amino groups. That reagent is di-tert-butyl dicarbonate, better known in the industry as BOC anhydride (CAS: 24424-99-5).
Why is peptide synthesis inseparable from it?
Amino acids are the building blocks of peptides, but free amino groups are too reactive—they tend to “wander off” during stepwise assembly, generating numerous side reactions. BOC anhydride wraps amino groups in a stable “protective shell” before reactions. This shell holds up against bases, nucleophiles, and reducing agents, keeping amino groups “quiet” through multiple reaction steps. When the time comes, it can be gently removed using dilute acids such as trifluoroacetic acid, without damaging other functional groups in the molecule.
This unique balance of “stable protection, gentle deprotection” makes BOC anhydride a standard reagent in solid-phase peptide synthesis (SPPS). It is widely used in high-end pharmaceutical fields including peptide drugs, antibiotics, and antibody-drug conjugates (ADCs), and also extends to fine synthesis applications in cosmetics and food additives.
Shunxiang’s Edge: 20 Years of Expertise, 5,000 Tons Annual Capacity
Nanjing Shunxiang Pharmaceutical is a pioneer in BOC anhydride production in China, with nearly 20 years of process expertise. Through continuous technological optimization, Shunxiang’s BOC anhydride consistently delivers purity above 99%, with a clear and controllable impurity profile—fully meeting the stringent requirements of pharmaceutical-grade intermediates.
Capacity matters even more. With an annual output of 5,000 tons, Shunxiang guarantees stable delivery and more controllable costs amid the surging demand for peptide drugs. Packaging options range from 25kg plastic drums to 200kg steel-plastic composite drums, flexibly matching every scale from lab R&D to industrial production.
Recognized as an outstanding supplier by leading domestic and international pharmaceutical companies for consecutive years, Shunxiang earns this trust not through slogans, but through the quality consistency of every single batch. As the peptide sector keeps accelerating, choosing an intermediate partner that can keep pace is itself a competitive advantage.