Pyridinium p-toluenesulfonate: High-efficiency catalysis, safe and reliable

Pyridine p-toluenesulfonate (PPTS) is a commonly used catalyst in organic synthesis, which is not strong acid or corrosive, but has a stable reaction effect and is particularly suitable for laboratory and small-scale production.
Efficient catalysis:
-Only 0.1 to 0.5 equivalents can significantly accelerate the reaction rate, much less than traditional acid catalysts.
-It exhibits stability, high yield, and minimal by-products in reactions such as hydroxyl protection, deprotection, esterification, and condensation.
-It can react at room temperature or slightly hot, without the need for high temperature and pressure, saving energy and time.
-It is friendly to complex molecular structures and does not damage sensitive groups such as aldehyde and vinyl bonds, making it suitable for the synthesis of pharmaceutical intermediates.
Safe and easy to use:
-Unlike concentrated sulfuric acid or hydrochloric acid, which corrode equipment, there is no damage to glassware and stainless steel reaction vessels.
-After the reaction, it is easy to separate and can be removed by simple washing with water or dilute alkali solution, without the need for complex purification.
-Solid powder, easy to weigh, can be directly added to the reaction system, with low operating threshold.
-Multiple domestic suppliers have stock available in small packages of 5g and 10g, suitable for scientific research and trial use.
Usage precautions:
-Easy to absorb moisture, seal immediately after opening and store in a dryer or refrigerator.
-When in contact with water, it will decompose. The reaction system must be dry, and the solvent needs to be treated without water.
-Dust may irritate the respiratory tract, so it is safer to wear a mask and gloves during operation and to use a fume hood.
-PPTS is not a panacea, but it plays an inconspicuous yet indispensable role in many synthetic routes. University laboratories, pharmaceutical research and development, and small-scale experiments in fine chemicals are all worth keeping as long as organic synthesis is done. The price is not high, with 99% purity costing less than 1 yuan per gram. It is economical to use, long-lasting, and has stable effects.